TL;DR
- Most people with myoclonic seizures have healthy pregnancies when seizures are controlled and meds are managed. Don’t stop meds suddenly-call your neurologist/obstetrician.
- Best-studied safer meds in pregnancy: lamotrigine and levetiracetam. Avoid or minimise valproate if possible due to higher birth defect and developmental risks.
- Start folic acid early. Many guidelines suggest 4-5 mg daily before conception and through the first trimester if you have epilepsy or take antiepileptic drugs.
- Plan monthly drug-level checks for lamotrigine/levetiracetam; doses often need to go up in pregnancy and down after birth.
- Have a birth and rescue plan, protect sleep, and set up home/baby-care safety tweaks. Breastfeeding is usually okay with most epilepsy meds.
Pregnancy changes your body in ways that can nudge seizure patterns and drug levels. The good news: with a plan, you can reduce risk. This guide turns a scary unknown into clear steps backed by major guidelines (AAN/AES 2019, ILAE 2020, ACOG 2023, and RANZCOG 2022-2024).
What to Expect: How Pregnancy Can Affect Myoclonic Seizures
Myoclonic seizures are quick, shock-like jerks-often on waking, sometimes in clusters, and often triggered by sleep loss, stress, or flashing lights. In conditions like Juvenile Myoclonic Epilepsy (JME), mornings and missed sleep are the classic setup. During pregnancy, two big forces act on seizures: hormones and drug metabolism.
Here’s the pattern many notice:
- Sleep gets messy. First trimester nausea and third trimester discomfort mean broken nights. Sleep loss is a key trigger for myoclonic jerks.
- Drug levels drift. Lamotrigine and levetiracetam clear faster in pregnancy-lamotrigine levels can drop by 50-70%, levetiracetam by ~30-50%. You may feel more jerks unless doses are adjusted.
- Morning sickness can cause missed doses, poor absorption, and breakthrough seizures. A backup plan for vomiting matters more than most people think.
- Hormones and fluid shifts can subtly change brain excitability. Some see no change, some improve, and some get more jerks-especially if sleep is thin or doses lag behind changing levels.
Risk to the baby from brief myoclonic jerks is usually low. The bigger concerns come from falls, injuries, or if myoclonic seizures cluster and generalize into tonic-clonic seizures. That’s why an early, precise plan is worth it.
What do the experts say? The American Academy of Neurology and American Epilepsy Society (AAN/AES) and the International League Against Epilepsy (ILAE) agree on a few anchors: keep the lowest effective dose, aim for one medicine when possible, avoid or minimize valproate, use high-dose folic acid preconception, and monitor drug levels throughout pregnancy. Australian guidance from RANZCOG lines up with this approach.
Bottom line: you can keep control by anticipating the two pressure points-sleep and serum levels-and tackling nausea, dosing, and safety in a simple routine. If you’re reading this early, you’re already a step ahead.
How to Prepare: A Trimester-by-Trimester Game Plan
Use this as your roadmap whether you’re planning a pregnancy or you’re already expecting.
Preconception (ideal: 3-6 months before trying)
- Book a med review. Ask about switching off valproate or topiramate if possible. For myoclonic seizures, levetiracetam or lamotrigine (or both) are common alternatives with better pregnancy safety data. Don’t change anything without your specialist.
- Start folic acid. Most epilepsy guidelines recommend 4-5 mg daily for people on antiepileptic drugs, beginning at least one month before conception. Keep at least through the first trimester.
- Get baseline drug levels. A pre-pregnancy trough level becomes your “target” to match during pregnancy.
- Check contraception facts. Enzyme-inducing medicines (carbamazepine, phenytoin, phenobarbital, primidone, high-dose topiramate) can reduce hormonal contraceptive efficacy. Consider an IUD or discuss dosing/backup methods with your GP.
- Create a trigger shield. Sleep routine, stress plan, and a strategy for screen time/photosensitivity if that’s a trigger.
- Safety at home. Shower instead of bathing alone, use a shower chair if needed, cook on rear burners, and add non-slip mats.
First trimester
- Lock in monthly level checks for lamotrigine and/or levetiracetam. Adjust doses to maintain your pre-pregnancy trough level or symptom control.
- Beat morning sickness. Take meds with a small snack; split doses if approved; use prescribed pregnancy-safe antiemetics. If you vomit within an hour of a dose, ask your team about re-dosing rules.
- Keep folic acid going. If you haven’t started, start now and speak with your doctor about the dose.
- Book standard scans (12-week and 20-week). Many teams add a detailed anatomy scan, especially if using older medicines with higher risk profiles.
Second trimester
- Stay on the level checks. Metabolism may keep speeding up until late pregnancy.
- Vitamin D and calcium. If you’re on enzyme-inducing meds, ask about bone health screening and supplements. Enzyme inducers can affect bone density over the long term.
- Draft your birth plan. Include who manages rescue meds during labour, how to keep you on time with doses, and IV access on admission.
- Update safety and work routines. Avoid heights/ladders, lock in consistent breaks, and ask for reasonable adjustments if your job is high risk.
Third trimester
- Finalise the hospital plan. Pack meds in original boxes, include a dose schedule card, and note your last serum levels.
- Discuss vitamin K. In Australia, newborn vitamin K at birth is routine. If you’re on enzyme-inducing ASMs, ask your obstetrician whether maternal vitamin K late in pregnancy is recommended for you.
- Set your sleep plan for after birth. Line up night help for feeds where possible, or consider pumped milk for one night feed to protect a block of sleep.
- Confirm rescue protocol. Who administers it, when, and what dose? Your team should put this in the chart.
Postpartum
- Expect dose reductions. Lamotrigine and levetiracetam levels rebound quickly-often within days to a couple of weeks. Plan to step doses back to pre-pregnancy levels as guided by levels and symptoms.
- Guard sleep. Myoclonic jerks love sleep loss. Share night duties, nap once daily, and avoid skipping doses.
- Breastfeeding. Usually compatible with most epilepsy meds. Watch your baby for unusual sleepiness or poor feeding, especially if you take benzodiazepines or phenobarbital.
- Contraception. Enzyme-inducing meds reduce combined pill effectiveness. Consider a copper or hormonal IUD, or discuss progestin-only options with your GP. Combined pills can lower lamotrigine levels-flag this before starting.

Medicines, Risks, and Monitoring: What You Need to Know
Staying on the right medicine at the right dose is the single strongest way to protect both you and your baby. Major societies (AAN/AES, ILAE, ACOG, RANZCOG) converge on these core points:
- Use the lowest effective dose.
- Prefer monotherapy when possible.
- Avoid or minimise valproate, especially in the first trimester, due to higher risks of major congenital malformations and long-term neurodevelopmental issues. If valproate is the only drug that controls your seizures, close monitoring and the lowest effective dose are key.
- Start high-dose folic acid early and keep your levels checked through pregnancy.
Here’s a quick, practical comparison:
Medicine | Pregnancy risk summary | Notes in pregnancy |
---|---|---|
Lamotrigine | Good safety data; no major rise in birth defects in large registries. | Levels often fall 50-70%. Check monthly; dose up in pregnancy, down postpartum. |
Levetiracetam | Good safety data; low malformation rates in registries. | Levels may drop 30-50%. Monitor monthly; adjust as needed. |
Valproate | Higher risks of malformations and developmental delay; dose-dependent. | Avoid/minimise. If essential for control, use lowest effective dose and high-dose folate, plus detailed fetal imaging. |
Topiramate | Increased risk of oral clefts and low birth weight. | Avoid if possible; if used, discuss extra monitoring. |
Carbamazepine | Moderate risk; better than valproate, higher than lamotrigine/levetiracetam. | Consider folate 4-5 mg; watch bone health with long-term use. |
Oxcarbazepine | Data suggest lower risk than carbamazepine but fewer long-term studies. | Monitor sodium; discuss folate dosing. |
Zonisamide | Limited data; possible low birth weight risk. | Use only if needed; add growth monitoring. |
Clonazepam | Can help myoclonic clusters but may cause neonatal sedation if high doses near delivery. | Use the smallest effective dose; plan taper if possible. |
Phenobarbital/Phenytoin/Primidone | Older inducers with higher risk profiles. | Use only if necessary; ask about vitamin K and bone health plans. |
Folic acid: Why the bigger dose? Several guidelines (AAN/AES 2019; RANZCOG 2022) recommend 4-5 mg daily for people with epilepsy, especially when taking enzyme-inducing medicines or valproate. The higher dose aims to lower neural tube defect risk and may support neurodevelopment. Timing matters: start before conception and continue at least through the first trimester.
Therapeutic drug monitoring: Set a schedule. Monthly checks for lamotrigine and levetiracetam work well for most. If your numbers fall below your pre-pregnancy level-or you feel more jerks-adjust sooner. After birth, reverse the process: drop doses back (often to pre-pregnancy targets) as levels rebound, and recheck within 1-2 weeks.
Rescue medicines: Work this out in writing. For generalised tonic-clonic seizures, many teams use hospital-administered benzodiazepines. For myoclonic clusters, some specialists add a small as-needed dose plan (for example, clonazepam), but this is personalised. Magnesium sulfate treats eclampsia-not epileptic seizures-so your chart should clearly say you have epilepsy.
Genetic risk: If a parent has epilepsy, a child’s lifetime risk of epilepsy is roughly 2-5%. JME can run in families, but most children will not have it. A genetics consult can help if there’s a strong family history.
Key rule of thumb: control trumps the “perfect” medicine list. A single well-controlled medicine beats multiple meds with breakthrough seizures. Never stop a medicine suddenly after you find out you’re pregnant-call your neurologist the same day.
Labor, Birth, and the Weeks After: Safety Without Fear
Labour is physical work, but it doesn’t have to be a seizure trigger if you build in the basics: hydration, food, on-time meds, and rest between contractions. Here’s what to expect and plan:
- Bring your meds. Keep them in original packaging. Ask the midwife to chart exact dosing times to match your home routine.
- IV access on admission. If you can’t swallow or you vomit, there’s a fallback.
- Pain relief. Epidurals are fine. Good pain control can reduce stress-related triggers.
- Lights and triggers. If photosensitivity is an issue, ask for dimmer lighting and avoid flashing monitors in your line of sight.
- Seizure protocol. Your birth plan should say who calls the shots, what rescue med is used for which seizure, and when to escalate.
Newborn care: In Australia, newborns receive vitamin K at birth, which helps prevent bleeding problems. If you were on enzyme-inducing medicines, your obstetric team may consider extra steps; ask during third-trimester planning.
Breastfeeding: Most antiepileptic drugs are compatible with breastfeeding. Lamotrigine and levetiracetam pass into milk but are usually well tolerated by infants. Watch for unusual sleepiness, feeding difficulty, or poor weight gain-especially if you take benzodiazepines or phenobarbital. If something feels off, check in with your paediatrician and neurology team.
Postpartum dose changes: Your pregnancy dose is often too high once the placenta is out. Lamotrigine and levetiracetam levels bounce back fast; plan a step-down to your pre-pregnancy dose (or close to it) within days to two weeks, guided by levels and symptoms.
Sleep protection: This is the most underrated piece. Myoclonic jerks love 2 a.m. feeds. If you can, share nights, use pumped milk for one feed, nap during the day, and move any high-risk tasks (like bathing baby) to times you feel your best.
Home safety with a newborn:
- Change nappies on the floor, not on elevated tables.
- Use baby baths with another adult present, or bathe baby when a support person is home.
- Use a pram with wrist strap on walks.
- If babywearing, choose a snug, front-facing carrier with good head support and avoid stairs when alone.

Checklists, Decision Tools, and Mini‑FAQ
Quick checklists you can print or save:
Preconception checklist
- Neurology review: can I switch off valproate/topiramate?
- Start folic acid 4-5 mg daily (earliest possible).
- Baseline drug levels + seizure diary started.
- Contraception fit for my meds (IUD often easiest).
- Safety tweaks at home (shower chair, cooking setup).
First trimester checklist
- Monthly lamotrigine/levetiracetam levels booked.
- Nausea plan: small meals, split doses if approved, antiemetic prescription.
- Don’t miss doses; if vomiting within 1 hour of a dose, follow your re-dose plan.
- 12-week scan booked; folic acid continued.
Second trimester checklist
- Level checks continue; dose adjusted to symptoms/targets.
- 20-week anatomy scan done; consider growth scans if on higher-risk meds.
- Start birth plan draft; list meds and rescue steps.
- Ask about vitamin D/calcium if on enzyme inducers.
Third trimester checklist
- Finalise birth plan and hospital bag (with meds and dose schedule).
- Discuss maternal vitamin K if on enzyme inducers; newborn vitamin K arranged.
- Set postpartum sleep plan and support roster.
- Confirm rescue protocol and who’s authorised to give it.
Postpartum checklist
- Book level check within 1-2 weeks after birth.
- Step doses down to pre-pregnancy targets as guided.
- Watch baby for sedation if on benzodiazepines/phenobarbital.
- Discuss contraception; flag lamotrigine-combined pill interaction.
Decision tool: If I discover I’m pregnant and I’m on valproate
- Don’t stop suddenly. Seizure rebound can be dangerous.
- Call neurology/obstetrics urgently. Ask for a fast-track review.
- Discuss switching to levetiracetam/lamotrigine (or a combo) if it can be done safely, or reducing valproate dose.
- Start/continue high-dose folic acid (4-5 mg daily) and book detailed fetal imaging.
- Set monthly level checks and a tight follow-up schedule.
Decision tool: If nausea makes me miss meds
- Try taking meds with a small snack, ginger tea, or cold foods to reduce smell-triggered nausea.
- Ask for pregnancy-safe antiemetics and a written re-dose rule.
- If vomiting within an hour of a dose, follow your plan. If it keeps happening, call your team the same day for alternatives or split dosing.
- Consider dissolvable or liquid formulations if available.
Mini‑FAQ
Will pregnancy make my myoclonic seizures worse?
Not always. Many stay stable. If seizures do worsen, common reasons are sleep loss, lower drug levels, and missed doses from nausea. Fixing those usually helps.
What’s the right folic acid dose?
If you have epilepsy or take antiepileptic drugs, several guidelines recommend 4-5 mg daily starting before conception and through the first trimester. Ask your doctor what’s right for you.
Is breastfeeding safe on lamotrigine or levetiracetam?
Usually yes. Watch for unusual sleepiness or feeding issues in your baby and report concerns. Many people breastfeed successfully on these meds.
What if I miss a dose or vomit after taking it?
If you remember within a few hours, take it as soon as you can unless you’re close to the next dose. If you vomit within an hour, follow your re-dose plan from your doctor. Keep things consistent and call if it becomes a pattern.
Can I use CBD for seizures in pregnancy?
Data in pregnancy are limited and quality is variable. Most specialists avoid CBD products during pregnancy unless part of a supervised plan. Stick with your prescribed medicines.
Do I need to stop driving?
Follow your local driving rules (Austroads guidelines in Australia). If you’ve had a recent seizure, you may need a seizure-free interval before driving again. Ask your doctor to clarify the current rules in your state.
Do I need extra scans because I have epilepsy?
Not always, but if you’re on a higher-risk medicine or doses have been hard to control, your team may suggest extra detailed ultrasounds and growth scans.
Is labour more dangerous if I have epilepsy?
Not usually, if your seizures are controlled and you stay on your meds. Your team will plan for rescue medication just in case.
Pro tips and pitfalls
- Rule of one: one medicine, one lowest effective dose, one change at a time.
- Set phone alarms for doses. Pregnancy brain is real; alarms save you.
- Keep a tiny snack kit and a backup dose in your bag for mornings on the go.
- Tell your birth team you have epilepsy so they don’t confuse a seizure with eclampsia (different treatments).
One last anchor to hold in your mind: well-controlled myoclonic seizures in pregnancy almost always lead to healthy mums and healthy babies. The trick is planning, not perfection.
Sources used while writing this piece include consensus and guideline documents from AAN/AES (2019), ILAE (2020), ACOG (2023), and RANZCOG (2022-2024), plus large pregnancy registry data on antiepileptic drug safety. Talk with your own clinicians for personalised advice.